The pharmacokinetic peculiarities include the speed of suction into the body, components’ breakdown in the human’s organism, the processes of metabolism, and the final removal from the tissues of the body.
Suction into the body
Viagra Soft gets absorbed very fast. This substance’s condensation in the blood reaches the most significant effect during 20 minutes…2 hours (after consumption on an empty stomach). The period is 1 hour, on average.
Full biological aptitude of the indicated remedy totals 40%. The biological aptitude interval varies on 25%-63%. After consumption of the indicated remedy (in the amount of 25-100 milligrams), the pharmacokinetics is always lineal. Following the usage of this remedy jointly with any high-caloric food, the suction period gets significantly lower.
Concentration of remedy
The concentration of key component’s distribution (which is Sildenafil in static location) totals about 105 liters, which denotes its distribution in genitals’ muscles. The principal component, which makes M-dimethyl metabolite circulate, is connected with the blood proteins at 96%.
The remedy’s concentration doesn’t depend on the connection with proteins. The healthy probationers had concentration reaching 0.0002%. It was found in the man’s semen after half an hour of the substance’s consumption. After one consumption of 100 mg, 188 ng-indicator was found.
Metabolism issue
Sildenafil accumulates only under the CYP3A4 influence, both as in a primary way with CYP2C9 and in the other one through the liver’s microsomal isozyme. Because of selectivity of influence, which it has on phosphodiesterase, the metabolism’s comparable to Sildenafil substance. Its accrual for PDE-5 is compiled by 50% compared to the intensification of the remedy itself.
The concentration in blood’s about 40% compared to the concentration of Sildenafil. M-dimethyl metabolite passes through the further processes of metabolism. The final period of partial elimination’s is four hours.
Elimination
The period for Sildenafil removal totals 41 liters/hour. The longest period of partial elimination can be up to five hours. After some time of consumption of the substance, it gets eliminated by generating metabolites (80% of the medicine taken) with the dejection & urine (about 20% or less).
